Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents

Studies on electron beam induced DNA damage and repair kinetics in lymphocytes by alkaline comet assay

Background: Exposure to ionizing radiation is known to induce oxidative stress followed by damage to critical biomolecules like lipids, proteins and DNA through radiolysis of cellular water. Since radiation has been widely used as an important tool in therapy of cancer, the detailed investigation regarding the DNA damage and repair kinetics would help to predict the radiation sensitivity of cel...

Malmquist productivity index in several time periods on interval data

The productivity change of a decision making unit (DMU) between two time periods can be evaluated by the Malmquist productivity index. In this study, we propose a method to compute the Malmquist productivity index in several time periods (from the first to the last periods) on interval data in data envelopment analysis (DEA). Then, the obtained Malmquist productivity index is compared with Malm...

Studies on the gene expression of several NADPH oxidase components.

Introduction The NADPH oxidase is an enzymic system found in professional phagocytes (neutrophils, eosinophils, monocytes and macrophages) that catalyses the one-electron reduction of oxygen to 0; [ 11. This 0; and the toxic oxygen molecules derived from it are produced by phagocytes during the process of respiratory burst after exposure to appropriate stimuli, and are used for the killing and ...

Studies on several 7-substituted N,N-dimethyltryptamines.

Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me- and 5-OMe-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself. Like DMT, all three of these compounds produce behavioral effects in rats which are simila...

On several classes of monographs